[HTML][HTML] Life cell imaging of amiodarone sequestration into lamellar bodies of alveolar type II cells

T Haller, A Jesacher, A Hidalgo, C Schmidt - Toxicology in Vitro, 2024 - Elsevier
… of amiodarone, we propose that passive diffusion, ion-trapping and lipophilic interactions are
… Furthermore, we demonstrate that measurement of amiodarone autofluorescence is highly …

The role of amiodarone in contemporary management of complex cardiac arrhythmias

N Mujović, D Dobrev, M Marinković, V Russo… - Pharmacological …, 2020 - Elsevier
… There are no data on interactions between amiodarone and apixaban [54]. Therefore, a …
interactions with amiodarone. In selected patients at high risk of bleeding who take amiodarone, …

Animal models of drug-induced pulmonary fibrosis: an overview of molecular mechanisms and characteristics

S Li, J Shi, H Tang - Cell Biology And Toxicology, 2022 - Springer
… surface in reduce the susceptibility to BLM cytotoxicity. Thus, … Potential mechanisms of the
amiodarone induced lung … induced gene expression in a human lung epithelial cell line (BEAS-…

[PDF][PDF] Amiodarone and thyroid dysfunction

F Medić, M Bakula, M Alfirević, M Bakula, K Mucić… - Acta clinica …, 2022 - hrcak.srce.hr
… is destructive thyroiditis caused by amiodarone, desethylamiodarone as its main metabolite,
cell lysis11,49. These results support the fact that amiodarone achieves most of its cytotoxic

[PDF][PDF] A REVIEW ON CLINICAL ASPECTS OF AMIODARONE

JVS CHANDANA, GSRI MEGHANA, B AASHRITHA… - 2023 - researchgate.net
Desethylamiodarone is the primary metabolite which is electro physiologically … of cytotoxic
T cells in bronchoalveolar lavage fluid. Amiodarone treatment can lead to various pulmonary

Amiodarone: a comprehensive guide for clinicians

D Hamilton, S Nandkeolyar, H Lan, P Desai… - American Journal of …, 2020 - Springer
… Therefore, we recommend that amiodarone should be taken with meals. Amiodarone is
metabolized in the liver to desethylamiodarone [5]. During loading, it goes through three phases …

A nontrivial differential diagnosis in COVID-19 pandemic: a case report and literary review of amiodarone-induced interstitial pneumonia

L Cappannoli, A Telesca, R Scacciavillani… - Future …, 2021 - Future Medicine
amiodarone-induced apoptosis of alveolar epithelial cell, that in turn plays a central role in
the development of acute lung … possible mechanisms: a direct cytotoxic effect or an immuno-…

Integrating distribution kinetics and toxicodynamics to assess repeat dose neurotoxicity in vitro using human BrainSpheres: a case study on amiodarone

C Nunes, S Proença, G Ambrosini, D Pamies… - Frontiers in …, 2023 - frontiersin.org
… , mono-N-desethylamiodarone (MDEA), was not detected in the cells or medium extracts (…
, and cells within the first 24 h after exposure to non-cytotoxic 1 µM amiodarone. Concentration…

[HTML][HTML] Amiodarone but not propafenone impairs bioenergetics and autophagy of human myocardial cells

A Krajčová, V Němcová, M Halačová, P Waldauf… - Toxicology and Applied …, 2023 - Elsevier
Cell viability and cytotoxicity assays in primary human cardiac … In conclusion, our
findings from in vitro experiments on human cardiac cell lines reveal that amiodarone, but not …

[PDF][PDF] Crucial Role of Mitochondrial Mechanisms in the Antineoplastic Effects of Desethylamiodarone

RF HJ - 2023 - pea.lib.pte.hu
… , epithelial cells of the hair and the intestine, red and white … tumor cells start to escape
and resist therapy agents (cytotoxic … Thereby, mono-N-desethyl amiodarone (Desethylamiodarone-…